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  • Mentorship and Supportive Supervision for Laboratories that support Surveillance of disease outbreaks for Emergence preparedness and readiness.

    Mentorship and Supportive Supervision for Laboratories that support Surveillance of disease outbreaks for Emergence preparedness and readiness.

    Clinical laboratories in Malawi form the foundation of evidence-based patient treatment and care. They are a fundamental component of disease surveillance, diagnosis and monitoring at every level of the healthcare system. Microbiology is one of the services offered by clinical laboratories to guide clinicians in antibiotic prescription and monitoring of antimicrobial resistance trends among pathogens of medical importance.

    Laboratories require competent human resources, material support, continuous supervision and mentorships to carry out tests and produce good-quality and reliable results. In Malawi, the District Public Hospital and Christian Health Association of Malawi (CHAM) laboratory services have suffered from inattention and chronic under-development with minimal resources for microbiology services.

    Recently the Government of Malawi, Ministries of Health through the Public Health Institute of Malawi (PHIM) has increasingly prioritised the quality of microbiology testing services by incorporating the implementation of quality management systems improvement and capacity-building activities into laboratory service work plans.

    Laboratory officer happily showing the intended result from culture.

    One of the improvement strategy is to train more laboratory staff in basic microbiology and to scale up number of laboratories that could conduct microbiology testing.

    Mr Yollam Chavula , Principle Laboratory Scientist responsible for technical microbiology work at NPHL and team.

    Miss Khumbo Maseko a microbiologist at NPHL demonstrating culture and sensitivity tests at one of the laboratories in Malawi

    Mr. Hurry Milala observing how a mentored laboratory staff performs drug sensitivity testing.

    PHIM through National Microbiology Reference Laboratory (NMRL) holds a critical role in rapid response to infectious diseases. Among its mandates, the NMRL leads Malawi’s laboratory microbiology-based surveillance and disease control services through the detection of pathogens using microbiology techniques. It has a plan to have a network of district and Mission laboratories capable of conducting culture and sensitivity testing to confirm disease outbreaks.

    It is for this reason that NMRL planned to conduct supportive supervision and mentorship for 9 laboratories including Machinga, Chiradzulu, Phalombe, Mulanje DHO, Mulanje Mission, Nsanje, Chikwawa, Malamulo mission and Nguludi (ST Joseph mission).

    The activity involved the preparation of culture media, doing quality checks for the prepared culture media, and culturing patients’ samples. The activity also involved organism identification, drug sensitivity testing (AST) and how to report results.

    Staff from NPHL attending morning handovers as a means of sensitisation to utilise microbiology results in the patients’ management.

    The team also had an opportunity to attend daily district hospital morning reports as a means of sensitizing clinicians and nurses to use laboratory as evidence in the management of patients.

    Commenting on the activity, the deputy director Mr Joseph Bitilinyu Bangoh who is also the head of the National Public Health Laboratory, highlighted that microbiology activities play a crucial role in patient management, outbreak investigations and disease surveillance. He again said that no surveillance is complete without a laboratory and that laboratory workers need to be vigilant when it comes to disease investigations. He sympathetically said that sometimes Public Health issues go without answers, citing a recent Neno outbreak and conjunctivitis that cost mortality and morbidity among children attending primary schools. He further said that emergency outbreaks like the Neno disease need to be responded to rapidly by the laboratory so that intervention are mitigated and implemented promptly.  He encouraged those who went for mentorship and supervision to work hard and provide quality mentorship skills so that microbiology in Malawi gives proper answers to outbreaks and other health needs. He promised the team that he was in support of the activity and in his capacity as deputy director PHIM, he would make sure that NPHL is involved in all disease surveillance and outbreak investigations.

  • Mpox (Training of Trainers) ToT by Public Health Institute of Malawi Countrywide.

    Mpox (Training of Trainers) ToT by Public Health Institute of Malawi Countrywide.

    Empowering Healthcare Workers to Combat Mpox Outbreak.

    19-09-2024, Mponela, Dowa District, Malawi – Dr Mwale [front-left] and ToT 4th Session team.

    The Public Health Institute of Malawi (PHIM) has recently been conducting sessions of a critical Training of Trainers (ToT) workshop on Mpox countrywide. The Fourth session of the Mpox ToT took place in Mponela, Dowa District from 19th – 20th of Sepetember, 2024. Dr. Annie Chauma Mwale, Deputy Director for PHIM drew attention on, as she made opening remarks, that the exercise aims to strengthen the HCW capacity on districts preparedness for Mpox, as  South Africa and Democratic Republic of Congo are reporting Mpox cases.

    Mpox ToT 4th Sessions participants.

    This initiative aimed to equip healthcare workers [Clinicians, IPC Officers, HPOs, IDSR Coordinators, DEHOs, Pharmacists, Dermatologists, HIV Officers, Point of Entry Officers and Laboratory Officers] from Ntchisi, Kasungu, Rumphi, Likoma, Nkhotakota, Salima with the essential knowledge and skills to effectively manage and prevent the spread of the Mpox virus.

    Facilitation in process by Dr. Nyembezi on Mpox Treatment.

    The ToT program covered a wide range of topics like Mpox epidemiology and transmission: Understanding the nature and spread of the virus. Clinical presentation and diagnosis: Recognizing the signs and symptoms of Mpox. Case Management and treatment: Implementing appropriate care and treatment strategies. Public health response: Coordinating prevention and control measures, and many more.

    By training healthcare workers as trainers, PHIM is empowering the Healthacare workers in the districts to cascade their knowledge and skills to a wider network of frontline health workers, ensuring a more comprehensive response to the Mpox outbreak. The Mpox ToT workshop is a significant step towards strengthening capacity to combat the virus and protect public health of the Republic of Malawi.

  • Direct Detection and Nanopore Sequencing of Poliovirus workshop at National Public Health Laboratory, Dar es Salam – Tanzania

    Direct Detection and Nanopore Sequencing of Poliovirus workshop at National Public Health Laboratory, Dar es Salam – Tanzania

    National Public Health Laboratory, Dar-es-Salam – Tanzania  [26/08/2024].

    The World Health Organisation (WHO) hosted a training on the Direct Detection and Nanopore Sequencing (DDNS) technique at the National Public Health Reference Laboratory in Dar es Salam, Tanzania from 26th August to 30 August 2024. The participating countries were Tanzania, Eritrea, Rwanda, Malawi and Kenya.

    Mr. Happy Manda and Mr. Mphatso Bukhu listening attentively to one of the lectures.

    Malawi was represented by Mr Mphatso Bukhu and Mr Happy Manda. The training was opened by the Deputy Director of Tanzania Public Health Institute who in her words encouraged the participants to be participative and facilitate networking in the family of the public health laboratories in Africa. She further emphasised working together in the fight against outbreaks with a citing as an example of the current Mpox pandemic that is threatening African countries.

    The workshop targeted sequencing of poliovirus using Nanopore technology. Poliomyelitis (polio) is a highly infectious and sometimes fatal disease caused by a virus. Polioviruses are small single-stranded RNA viruses that belong to the Enterovirus subgroup of the family Picornaviridae. Humans are the only reservoir for the polio virus. The virus invades the nervous system and can cause irreversible paralysis. The disease usually affects children under five years.

    Practicing time in a genomics laboratory

    Polio cannot be cured, but safe vaccines can effectively prevent the disease. When administered multiple times, a proper polio vaccine can protect a child from this disease for life. Despite the substantial progress made by the Global Polio Eradication Initiative (GPEI), poliomyelitis remains a major health problem in under-immunized communities. Emerging poliovirus transmission and current outbreaks of circulating vaccine-derived poliovirus (cVDPV) are such setbacks to the GPEI. Furthermore, a combination of delayed receipt (shipping) of stool samples, time taken for virus isolation using cell culture and insufficient sequencing capacity result in delay of outbreak interventions. The Global Polio Surveillance Action Plan (GPSAP) 2022-2024 aims to increase the speed of poliovirus detection, improving surveillance and timely intervention campaigns.

    Multi – country participants listening attentively

    Direct Detection by Nanopore Sequencing (DDNS) allows rapid molecular detection and sequencing of poliovirus from stool samples in a simple integrated protocol. It replaces cell culture, intratypic differentiation (ITD) and Sanger sequencing, allowing case confirmation by generating a VP1 sequence in less than 7 days of sample processing. It can be performed in any laboratory with experience conducting PCR, bringing sequencing capacity to many more Global Polio Laboratory Network (GPLN) laboratoriess. This improved next-generation sequencing method is currently being validated for implementation with ongoing successful parallel testing in priority Polio labs and the method offers an opportunity to interrupt ongoing transmission of polioviruses of programmatic importance.

    Participants went away with certificates.

    In laboratories which are not part of the Global Polio Laboratory Network (GPLN) laboratories like Malawi, considering the Global Action Plan for Containment of polioviruses, it is imperative to prepare a comprehensive SOP to guide the handling, processing, and containment of stool specimens for poliovirus detection by Direct Detection and Nanopore Sequencing (DDNS). This will improve poliovirus detection and monitoring in countries whose laboratories are not part GPLN within the WHO-AFRO region.