MPOX – Malawi Situation.
by
Moses Nyambalo Phiri in collaboration with Grace Funsani, Noel Khunga, Chriswell Nkoloma and Settie Kanyanda.
The Public Health Institute of Malawi (PHIM) has announced a new laboratory-confirmed case of Mpox, bringing the total number of infections in the country to 71 since the first case was recorded on April 17, 2025.
The latest case is a 35-year-old male farmer from Senti in the Lilongwe district. He sought medical attention at Bwaila hospital on August 13, 2025, presenting with a range of symptoms including fever, muscle ache, fatigue, chest pain, shortness of breath, sore throat, and a distinct skin rash. According to the report, the patient also has an underlying health condition.
Samples were collected on the same day as his hospital visit, and subsequent testing confirmed the Mpox infection. The report notes that the individual has no recent travel history outside of Malawi
Malawi’s Coordinated Public Health Response
The Public Health Institute of Malawi has implemented a multi-faceted strategy using a One-Health approach to contain the outbreak, protect public health, and provide care.
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Activation
Incident Management System (IMS) Activated
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Collaboration
Multi-sectoral One-Health Surveillance
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Action
Rapid Response Teams Deployed
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Engagement
Risk Communication & Community Engagement
From April 17 up to mid early August, 2025…
Case Breakdown and Demographics
A total of 63 confirmed Mpox cases have been recorded, with 38 males and 25 females. The age range of those affected is between 2 and 75 years.
The majority of cases are in Lilongwe, which accounts for 49 of the confirmed infections. Other affected districts include Blantyre (3), Mangochi (3), Salima (2), and one case each in Ntcheu, Likoma, Nkhatabay, Mzimba South, Ntchisi, and Karonga.
Current Status of Patients
As of the latest report, 47 patients have recovered and been discharged from care. Two cases in Lilongwe were classified as lost-to-follow-up after proving difficult to trace. Currently, 14 confirmed cases are under clinical care. One patient is in hospital isolation in Lilongwe, while the other 13 are in home isolation across Lilongwe (10), Mzimba South (1), Ntchisi (1), and Karonga (1). No deaths have been reported.
Extensive contact tracing efforts by Rapid Response Teams (RRT) have identified 839 contacts. Of these, 830 have successfully completed their 21-day monitoring period without developing symptoms and have been discharged. Six contacts (four in Lilongwe and two in Blantyre) are still under active monitoring. Notably, five of the total traced contacts later tested positive for Mpox.
“One Health Approach” – Comprehensive Public Health Response:
The Ministry of Health, through PHIM, has implemented a multi-faceted response strategy, including:
Coordination: Activation of the Incident Management System (IMS) and development of a costed Mpox Incident Action Plan (IAP).
Laboratory: PCR testing of samples, genomic sequencing of MPXV, training of lab personnel, establishment of a molecular lab in Mzuzu Central Hospital, and distribution of viral transport media (VTM).
WASH & IPC: Development of training materials and IPC guidelines, IPC orientation in high-risk districts, adaptation of WHO rapid IPC/WASH assessment checklist, and construction of temporary latrines and bathing shelters at holding areas.
Risk Communication, Community Engagement & Social Mobilization (RCCE): Dissemination of messages in local languages (Chichewa, Tumbuka, Swahili, English) through various media, orientation of Chipatala Cha Pa Foni staff, and community engagements in affected areas.
Since the outbreak began, a total of 839 contacts have been identified and are being monitored daily by healthcare workers for a period of 21 days
Surveillance: Deployment of RRTs for detailed investigations and contact tracing, enhanced surveillance at community, facility, and Points of Entry (PoE) levels, daily contact follow-up, and dissemination of case definitions and reporting tools.
Case Management: Development and distribution of case management guidelines, identification of isolation facilities, training of health workers, and development of home-based care protocols.
Logistics: Distribution of essential medicines and PPEs, and setup of treatment units at Kamuzu Central Hospital and Bwaila Hospital.
Points of Entry (PoE): Intensified surveillance and awareness campaigns for travelers at all PoEs.
Vaccination: The PMRA has approved the use of the MVA-BN vaccine, following MAITAG’s recommendation. Country vaccine request and budget development are underway.
Challenges and Recommendations:
As stated ealrier above, that a total of 839 contacts have been identified and are being monitored daily by healthcare workers for a period of 21 days. And that
As of August 4, 2025, 830 contacts have completed their monitoring period without showing symptoms. Nine contacts are still being monitored, and five of the total contacts tested positive for Mpox.
PHIM recommends continued resource mobilization, cascaded training for healthcare workers, orientation of coordination structures, surveillance data reviews, engagement of key stakeholders in contact tracing, continued screening at Dzaleka refugee camp, fast-tracking lab reagent orders, and rapid IPC/WASH assessments in remaining health facilities and private clinics.
“The first case was recorded in Lilongwe district on April 16, 2025. Later additional cases were registered. All the cases are males within the age range of 2 to 38 years: a 30-year-old from Phwetekere- Area 36, a 33-year-old from Kawale 2, 38 year-old from Chilinde, a 35 year-old from Area 36, Kandikole, an 18 year-old from Area 36, Tumbwe, Traditional Authority (TA) Tsabango, Lilongwe district, and a two year-old child from Michesi 1 village, TA Mponda, Mangochi district.Three cases from Lilongwe have recovered and have been discharged from clinical care, while the other three are still under clinical care . No death has been reported.”
Grace Fusani – Mpox Incident Manager, PHIM.
Vincent Kamforzi, Data Manager – “The affected districts are Lilongwe, Mangochi, Ntcheu, Salima, Likoma, and NkhataBay.”
What response activities have so far been undertaken ?
PHIM has activated its Incident Management System (IMS) for Mpox and is working with various sectors, including animal health, civic education, and disaster management, using One Health Approach
1. Surveillance.
Rapid Response Teams (RRTs) have been deployed to conduct contact tracing and investigate cases. Surveillance systems have been enhanced at the community level, health facilities, and points of entry (PoEs).
The district team are being trained on Mpox through a collaborative effort involving Amref Health Africa, the US CDC, and the World Bank, which have provided the necessary resources. Initial training, supported by Amref Health Africa, has been conducted in the Chitipa and Karonga districts. This district level training will be extended to all districts to ensure comprehensive staff preparedness covering critical areas such as Mpox Etiology and Virology, Transmission Pathways, Prevention and Control Measures, and Clinical Management etc.
2. Case Management.
Case management guidelines have been developed and distributed, and isolation facilities have been identified.
3. Labolatory.
Samples from suspected cases are being tested using PCR, and genomic sequencing of the Mpox virus is underway.
Essential medicines and PPEs have been distributed to districts and Messages about Mpox prevention are being disseminated in local languages through various channels, including posters, social media, leaflets, and audio recordings. PHIM is working to address these challenges and will continue to provide updates on the situation.
[…] ministry of health has announced three new cases of mpox in the capital, Lilongwe, bringing the number of confirmed cases to 11 since the country’s first was reported in […]
[…] ministry of health has announced three new cases of mpox in the capital, Lilongwe, bringing the number of confirmed cases to 11 since the country’s first was reported in […]
[…] ministry of health has announced three new cases of mpox in the capital, Lilongwe, bringing the number of confirmed cases to 11 since the country’s first was reported in […]
[…] ministry of health has announced three new cases of mpox in the capital, Lilongwe, bringing the number of confirmed cases to 11 since the country’s first was reported in […]
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