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Malawi Delegation Joins Regional Peers for Intensive EIDM Program.
Mpox Outbreak Report – Malawi Mpox Outbreak in Malawi
Public Health Institute of Malawi (PHIM) Report | As of August 13, 2025
Total Confirmed Cases
70
Outbreak Start Date
April 17, 2025
Outbreak Progression
This chart illustrates the cumulative rise in laboratory-confirmed Mpox cases and the reported death since the outbreak began.
Note: A death was reported on August 11, 2025.
Latest Case Profile
A new case was confirmed on August 13, 2025, in Lilongwe District.
- ●Demographic: 35-year-old male, farmer from Senti
- ●Travel History: None outside Malawi
- ●Symptoms: Fever, muscle ache, fatigue, chest pain, shortness of breath, sore throat, and skin rash
- ●Status: With an underlying condition
What response activities have so far been undertaken ?
“The affected districts are Lilongwe, Mangochi, Ntcheu, Salima, Likoma, and Nkhatabay.” – Vincent Kamforzi, Data Manager-PHIM. PHIM has activated its Incident Management System (IMS) for Mpox and is working with various sectors, including animal health, civic education, and disaster management, using One Health Approach
Mpox Suspect in Lilongwe WHO IS AT RISK OF GETTING MPOX?
A person who has been exposed to an infected person during the infection period i.e., the period beginning with the onset of the index case’s first symptoms and ending when all scabs have fallen off, and who has one or more of the following exposures with a probable or confirmed case of mpox:
• direct skin-to-skin and skin-to-mucosal physical contact (such as touching, hugging, kissing, intimate or sexual contact)
• contact with contaminated materials such as clothing or bedding, including material dislodged from bedding or surfaces during handling of laundry or cleaning of contaminated rooms
• prolonged face-to-face respiratory exposure in close proximity
• respiratory exposure (i.e., possible inhalation of) or eye mucosal exposure to lesion material (e.g., scabs/crusts) from an infected person
• the above also apply for health workers potentially exposed in the absence of proper use of appropriate personal protective equipment (PPE)MPOX PROBABLE AND CONFIRMED CASE
Probable: A person presenting with an unexplained acute skin rash, mucosal lesions or lymphadenopathy (swollen lymph nodes). The skin rash
may include single or multiple lesions in the ano-genital region or 2 elsewhere on the body. Mucosal lesions may include single or multiple oral, conjunctival, urethral, penile, vaginal, or anorectal lesions. Ano-rectal lesions can also manifest as ano-rectal inflammation (proctitis), pain and/or bleeding. AND One or more of the following:
• has an epidemiological link to a probable or confirmed case of mpox in the 21 days before symptom onset
• has had multiple and/or casual sexual partners in the 21 days before symptom onset
• has a positive test result for orthopoxviral infection (e.g., OPXV-specific PCR without MPXV-specific PCR or sequencing). Confirmed: A person with laboratory confirmed MPXV infection by detection Confirmed of unique sequences of viral DNA by real-time polymerase chain case reaction (PCR)c and/or sequencing.MPOX SUSPECTED CASE
a) A person who is a contact of a probable or confirmed mpox
case in the 21 days before the onset of signs or symptoms,
and who presents with any of the following: acute onset of fever (>38.5°C), headache, myalgia (muscle pain/body
aches), back pain, profound weakness, or fatigue. OR A person presenting with an unexplained acute skin rash,
mucosal lesions or lymphadenopathy (swollen lymph nodes). The skin rash may include single or multiple lesions in the ano-genital region or elsewhere on the body. Mucosal lesions may include single or multiple oral, conjunctival, urethral, penile, vaginal, or anorectal lesions. Ano-rectal lesions can also manifest as ano-rectal inflammation (proctitis), pain and/or bleeding. AND For which the following common causes of acute rash or skin lesions do not fully explain the clinical picture: varicella zoster, herpes zoster, measles, herpes simplex, bacterial skin infections, isseminated gonococcus infection, primary or secondary syphilis, chancroid, lymphogranuloma venereum, granuloma inguinale, molluscum contagiosum, allergic
reaction (e.g., to plants); and any other locally relevant common causes of papular or vesicular rash. (N.B. It is not necessary to obtain negative laboratory results for listed common causes of rash illness in order to classify a case as suspected. Further, if suspicion of mpox or MPXV infection is high due to either history and/or clinical presentation or possible
exposure to a case, the identification of an alternate pathogen which causes rash illness should not preclude testing for MPXV, as co-infections have been identified.ProQuest-Ebooks central
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